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WHAT IS PLAQUE PSORIASIS?

Plaque psoriasis is an autoimmune disorder, a condition that causes your immune system to mistakenly target healthy tissue.

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Psoriasis pretends it’s just a skin condition

While its exact cause is unknown, plaque psoriasis (PSO) doesn’t begin with skin. It’s systemic, originating inside the body as a result of an overactive immune system. This overactivity leads to inflammation.

On the skin, this inflammation appears as an abnormal buildup of cells called plaques, which are raised, reddish, flaky, and scaly in appearance.

Take a look at the graphic below to see how psoriasis works in the body:

Skin with plaque psoriasis

When you have plaque psoriasis, overactive immune cells produce too many proteins, causing plaques to form on the skin’s surface.

Skin with plaque psoriasis.
BIMZELX treating plaque psoriasis

BIMZELX targets and binds the IL-17A and IL-17F proteins, which are key drivers of psoriasis. This eases the inflammation in the body and helps reduce the symptoms of plaque psoriasis.

BIMZELX treating plaque psoriasis.

The relationship between how BIMZELX works and clinical outcomes has not been determined.

Location and severity
of plaques

Plaques can show up anywhere on the body, but
people most often see them on the:

  • Scalp
  • Ear canals
  • Elbows
  • Lower back
  • Belly button
  • Soles of feet
  • Knees
  • Palms
  • Nails

Plaque psoriasis ranges from mild to moderate and severe. Moderate psoriasis affects 3-10% of the skin’s surface. Severe cases affect more than 10%.

One hand equals 1%.

You can use your hand as an approximate measure. For most people, your hand equals 1% of your skin’s surface area.

Locations and severity of plaques. 3-10% is moderate. Over 10% is severe.
Locations and severity of plaques. 3-10% is moderate. Over 10% is severe.
Person with plaque psoriasis.

Not an actual BIMZELX patient

Psoriasis is more
than what you see

If you struggle with plaque psoriasis, you know the surface is only part of the story. People with plaque psoriasis typically experience unseen symptoms like itching, pain, and impacts to their overall emotional health.

A survey from the National Psoriasis Foundation revealed that nearly 60% of people with psoriasis felt their condition intruded on everyday life.

Ask your dermatologist if BIMZELX is right for you. Download our brochure as a resource when talking to your dermatologist.


LOOKING FOR MORE SUPPORT?

The National Psoriasis Foundation works to find a cure for psoriasis and to eliminate its devastating effects through research, advocacy, and education. Call 1-800-723-9166 for questions about psoriasis.

Personalized resources that connect you to your treatment goals

Stay in the know
about bimzelx


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IMPORTANT SAFETY INFORMATION:

BIMZELX is a medicine that affects your immune system and may increase your risk of serious side effects, including suicidal thoughts and behavior, serious infections including tuberculosis, liver problems, and inflammatory bowel disease.

Indication: BIMZELX® is a prescription medicine used to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet light alone or with pills (phototherapy).

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about BIMZELX® (bimekizumab-bkzx)?

BIMZELX is a medicine that affects your immune system. BIMZELX may increase your risk of having serious side effects, including:

  • Suicidal thoughts and behavior have happened in some people treated with BIMZELX. Get medical help right away or call the National Suicide and Crisis Lifeline at 988 if you, your caregiver or your family member notice in you any of the following symptoms:
    • new or worsening depression or anxiety
    • thoughts of suicide, dying, or hurting yourself
    • changes in behavior or mood
    • acting on dangerous impulses
    • attempt to commit suicide
  • Infections. BIMZELX is a medicine that may lower the ability of your immune system to fight infections and may increase your risk of infections.
    • Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with BIMZELX.
    • If your healthcare provider feels you are at risk for TB, you may be treated with medicine for TB before you begin treatment with BIMZELX and during your treatment.
    • Your doctor should watch you closely for signs and symptoms of TB during and after treatment with BIMZELX. Do not take BIMZELX if you have an active TB infection.

Before starting BIMZELX, tell your healthcare provider if you:

  • are being treated for an infection
  • have an infection that does not go away or that keeps coming back
  • have TB or have been in close contact with someone with TB
  • think you have an infection or have symptoms of an infection such as:
    • fever, sweats, or chills
    • muscle aches
    • cough
    • shortness of breath
    • blood in your phlegm
    • weight loss
    • warm, red, or painful skin or sores on your body different from your psoriasis
    • diarrhea or stomach pain
    • burning when you urinate or urinating more often than normal

After starting BIMZELX, call your healthcare provider right away if you have any of the signs of infection listed above. Do not use BIMZELX if you have any signs of infection unless you are instructed to by your healthcare provider. See “What are the possible side effects of BIMZELX?” for more information about side effects.

What is BIMZELX?

BIMZELX is a prescription medicine used to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet light alone or with pills (phototherapy).

  • It is not known if BIMZELX is safe and effective in children.

Before using BIMZELX, tell your healthcare provider about all of your medical conditions, including if you:

  • have any of the conditions or symptoms listed in the section “What is the most important information I should know about BIMZELX?”
  • have a history of depression, or suicidal thoughts or behavior
  • have liver problems
  • have inflammatory bowel disease (Crohn’s disease or ulcerative colitis)
  • have recently received or are scheduled to receive an immunization (vaccine). You should avoid receiving live vaccines during treatment with BIMZELX.
  • are pregnant or plan to become pregnant. It is not known if BIMZELX can harm your unborn baby.
    • If you become pregnant while taking BIMZELX, you are encouraged to enroll in the Pregnancy Registry, which is used to collect information about the health of you and your baby. Talk to your healthcare provider or call 1-877-311-8972 to enroll in this registry or visit http://mothertobaby.org/pregnancy-studies/.
  • are breastfeeding or plan to breastfeed. It is not known if BIMZELX passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with BIMZELX.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

What are the possible side effects of BIMZELX?

BIMZELX may cause serious side effects. See “What is important information I should know about BIMZELX?”

  • Elevated liver enzyme levels. Your healthcare provider will do blood tests to check your liver enzyme levels before starting treatment and during treatment with BIMZELX. Your healthcare provider may temporarily stop or permanently stop your treatment with BIMZELX if you develop liver problems. Call your healthcare provider right away if you develop any signs or symptoms of liver problems, including:
    • pain on the right side of your stomach-area
    • feeling very tired
    • loss of appetite
    • nausea and vomiting
    • itching
    • dark urine
    • light-colored stool
    • yellowing of your skin or the whites of your eyes
  • Inflammatory bowel disease. New cases of inflammatory bowel disease or “flare-ups” have happened with BIMZELX. If you have inflammatory bowel disease (Crohn’s disease or ulcerative colitis), tell your healthcare provider if you have worsening disease symptoms during treatment with BIMZELX or develop new or worsening signs of Crohn’s disease or ulcerative colitis.

The most common side effects of BIMZELX include:

  • upper respiratory tract infections
  • headache
  • herpes simplex infections (cold sores in or around the mouth)
  • small red bumps on your skin
  • feeling tired
  • fungal infections (oral thrush or infections in the mouth, throat, skin, nails, feet, or genitals)
  • pain, redness, or swelling at the injection site
  • stomach flu (gastroenteritis)
  • acne

These are not all of the possible side effects of BIMZELX. Call your doctor for medical advice about side effects.

Use BIMZELX exactly as your doctor tells you to use it.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.